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Studies on similar GLP-1 peptides show that short-term temperature excursions (4-8 hours at room temperature) reduce potency by approximately 5-10%, which is noticeable but not dangerous

For this to evolve into a true long-term inflection in the equity story, I think we need to see three things: sustained high-dose oral Wegovy share with acceptable realworld discontinuation, visible progress on nextgeneration assets like amycretin, and at least one or two targeted transactions that deepen Novos moat in obesity and metabolic disease

Topical niacinamide studies typically use 2-5% concentrations applied directly to skin

Dermatologic disorders and the liver

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