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While these variants do not predict exact medication response or UC risk, they may help provide context for more personalized clinical conversations about safety and efficacy

GLP1RA, glucagon-like peptide-1 receptor agonist

The persistent presence of pathogens, such as viruses or bacteria, or their residual components (e.g., the spike protein of SARS-CoV-2), may function as pathogen-associated molecular patterns (PAMPs), continuously activating pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), thereby providing a potential foundational pro-inflammatory signal (122)

The connective tissue is still unstable