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In conclusion, we found that l-valine is a powerful stimulator of GLP-1 secretion both in rats and mice (ex vivo and in vivo), and we suggest a mechanism for l-valine stimulated GLP-1 release involving intracellular metabolism of the amino acid, leading to the closure of K ATP -channels, membrane depolarization and activation of V-gated Ca 2+ -channels (Fig
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Both animal and human studies have shown that increased GLP-1 activity reduces intestinal motility [23]
Structural determinants for activity of glucagon-like peptide-2
Red flags requiring urgent medical attention include triglyceride levels 10 mmol/L (risk of pancreatitis) and suspected familial hypercholesterolaemia, which requires specialist referral
Dunbar JC, Lu H
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