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They should not be co-prescribed with DPP-4 inhibitors as this combination provides no additional benefit

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Level of evidence For individuals with a known diagnosis of diabetes or without a prior diagnosis but presenting with hyperglycemia, the use of HbA1c testing to guide inpatient glycemic management was evaluated as expert opinion, and the strength of the recommendation was rated as a general recommendation, based on the judgment that the potential benefits outweigh the harms

Traditional options like orlistat and phentermine-topiramate primarily function by either preventing fat absorption or suppressing appetite

doi: 10.3390/ijms21144946