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Common adverse effects include nausea, vomiting, diarrhoea, fatigue, and potential hypoglycaemia, all of which significantly impair training capacity and athletic performance

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For patients with obesity-related comorbidities such as hypertension, dyslipidaemia, or fatty liver disease these combined effects could represent a clinically meaningful advance if confirmed in Phase 3 data

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation

This can contribute to: Gingivitis Periodontal pocket formation Increased bleeding and tenderness For patients with pre-existing periodontal disease, these changes may accelerate disease progression if not closely monitored