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Patients should be advised to stay well hydrated and report persistent or severe gastrointestinal symptoms to their healthcare provider
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Evidence from several clinical trials demonstrate that the combination of GLP-1 therapies with structured dietary and exercise interventions results in additive weight loss effects compared with either strategy alone
Second, despite accounting for many relevant covariates in the adjustment and employing IPTW techniques, we may have missed some potentially relevant information and thus we cannot rule out residual confounding
The researchers concluded that most of these hormonal changes (particularly TSH and free T3) appeared to be independent of weight loss, suggesting a possible direct effect of semaglutide on thyroid regulation that still needs to be clarified, while changes in free T4 were more closely related to weight change
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