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In a controlled study cited in the same review, participants who slept 5.5 hours per night lost less fat and more fat-free mass than those who slept 8.5 hours per night. The authors reported that sleep curtailment decreased the proportion of weight lost as fat by 55% and increased the loss of fat-free body mass by 60%. Poor sleep has also been linked to increased hunger and changes in appetite-regulating hormones

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Yet, as O'Donnell notes, on-again-off-again use is already in the cultural zeitgeist

( D ) IRI protocol of retrograde, nonrecirculating Langendorff perfusion of isolated hearts from male 10- to 12-week-old WT or Glp1r / mice