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Sestrin2 is a leucine sensor for the mTORC1 pathway

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We next used our established organoid model to test mitophagy and hair regeneration (Fig

Additionally, it is also crucial to evaluate whether free covalent inhibitors can be eliminated by metabolic enzymes in vivo during the development of covalent inhibitors

As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins