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Gastrointestinal Issues This is the most frequent complaint

A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility

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Because slowing the stomach is exactly what the drug is supposed to do, many patients experience side effects like nausea, vomiting, or feeling overly fullsymptoms that closely mimic gastroparesis [10] [11]

This highlights the need for improved methods to measure and quantify oxidative stress including male oxidative stress infertility biomarkers such as 8-hydroxy-2-deoxyguanosine, the use of omics studies, and DNA methylation panels [76,77]