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[10] Systemically dosing a copper-carrying peptide in someone with Wilsons disease or another copper-overload condition is conceptually contraindicated: it works against the entire therapeutic direction of the disease

Researchers are eager to explore its potential, but they're simultaneously navigating a sprawling and often misunderstood regulatory environment

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The albumin-binding chemistry was elegant and was validated at the bench: the identifying study showed that the maleimide-modified GHRH(1-29) conjugate activated the receptor and persisted in plasma for days in animals

But it also raises IGF-1, disrupts glucose metabolism, and can accelerate unwanted tissue growth