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The "effective dose" in a 250-gram rat does not translate directly to a dose for an 80-kilogram human

74 The accumulation of lipids in MDSCs increases oxidative metabolism, resulting in MDSC acquisition of an immunosuppressive and anti-inflammatory phenotype

Kossai, M., Leary, A., Scoazec, J

Remarkably, 4 weeks of treadmill running reversed these age-related changes, leading to higher IGF-1 and VEGF expression, upregulation of SIRT1 and SIRT3, and a shift toward a neuroprotective RAS profile