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[PubMed] 6

Chakravarthy explains

Semaglutide and tirzepatide, among other GLP-1 medications, have demonstrated: Significant weight reduction (often over 10% of body weight) Improved glycemic control Cardiovascular benefits (including lower risk of major adverse cardiac events) In pivotal trials like the STEP (semaglutide) and SURMOUNT (tirzepatide) studies, frequent in-person weight monitoring typically every 2 to 4 weeks was an integral component of optimizing these outcomes

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Painful and immobilizing joint conditions like osteoarthritis develop as a consequence of repeated stress on the joints