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The NLRP3 inflammasome is activated by lipid peroxidation byproducts such as 4-HNE and MDA produced during ferroptosis, triggering caspase-1-dependent maturation of IL-1/IL-18, which amplifies inflammation and establishes a vicious cycle (127, 131)

About the author Medical Director Aesthetic & Regenerative Medicine Leading Silk Clinics with years of experience in aesthetic medicine, Dr Ahmad Sadeqyar oversees clinical excellence across all departments and personally treats complex aesthetic cases

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stimulate the synthesis of collagen and other components of connective tissue

Many of the studies had small sample size and assessed only short-term outcomes