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FDA Evaluation of AOD-9604-Related Bulk Drug Substances (AOD-9604 (free base) and AOD-9604 acetate)

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Compared with the other medications, people taking the GLP-1 drugs had a reduced risk of addiction: 18% for alcohol, 14% for cannabis, 20% for both cocaine and nicotine and 25% for opioids

Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, de Gomez Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021) Microbiota-derived short chain fatty acids modulate microglia and promote A plaque deposition