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The published evidence base for CJC-1295 Without DAC draws on both the direct characterisation of the tetrasubstituted backbone and the extensive clinical and pre-clinical literature generated for CJC-1295 with DAC, which shares the same four amino acid substitutions and GHRH receptor pharmacology

No unattributed density was visible near the D-loop, but we cannot exclude transient interactions with SMAX1 regions other than the N or D2 domains

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We were particularly concerned about this limitation, as PCSK1 is lowly expressed in adult cells (16)