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In cancer cells, increased ROS will oxidize the specific isoform of pyruvate kinase (PKM2), diverting glucose flux towards the PPP and generation of NADPH for GSH recycling

When gut microbiota dysbiosis occurs, it can accelerate the onset process of osteoarthritis by consuming protective metabolites that inhibit ferroptosis [such as serotonin (5-HT) and 3-hydroxyanthranilic acid (3-HAA)] and increasing the levels of ferroptosis - promoting compounds [such as lipopolysaccharide (LPS)]

But where consultations are brief or asynchronous, the opportunity for extended nutritional and lifestyle counselling is reduced, and that gap needs to be identified and addressed at a system level, not left to individual patients to navigate alone