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BBB dysfunction also increases with aging, which is an important risk factor for COVID severity 48,49

Increased Hunger and Cravings: Hormonal imbalances can lead to increased appetite and poor control over food intake, leading to weight gain

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doi: 10.3389/fphar.2025.1662316 Received 09 July 2025 Accepted 06 October 2025 Published 20 October 2025 Volume 16 - 2025 Edited by Olga Kopach, St Georges, University of London, United Kingdom Reviewed by Manuel L

[1] [2] It functions primarily within the mitochondriathe cellular powerhouseswhere it participates in the electron transport chain to generate adenosine triphosphate (ATP), the body's primary energy currency