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For academic investigative sites that did not receive a waiver to use the central IRB, full board approval was obtained from the respective governing IRBs, and documentation of approval was submitted to CorEvitas, LLC, prior to the initiation of any study procedures

Nasal sprays bypass digestion entirely, offer higher baseline bioavailability, and provide a direct pathway to the brain

TABLE 2 Differential diagnosis of diseases with clinical manifestations similar to neurological damage caused by N 2 O abuse

Maraming, P

As expected, and consistent with a reduced interaction of the amidated C-terminal tyrosine with the CTR ECD, CagriP37Y presented a lower potency than Cagri in cells expressing CTR alone (Supplementary Fig