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Recent enzymatic analyses in lymphocytes showed that BD patients in the depressive phase had lower levels of mitochondrial complex II activity compared to those in the euthymic phase, with a significant negative correlation between the Hamilton Depression Rating Scale score and mitochondrial complex II activity [50], providing a strong link between reduced mitochondrial function and current bipolar depressive phase

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Zhang W, Konopleva M, Y-X S, Harris D, Small D, Ling X, Estrov Z, Cortes J, Andreeff M