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This suggests that si-PGC-1 carried by LNP exhibits superior tissue penetration within the tumor and has a more extensive distribution compared to the unencapsulated si-PGC-1 group

IV delivery offers the advantage of bypassing digestion, achieving higher absorption, and enabling more precise dosing

However, individual variation in gastric function means that optimal timing remains a personalized factor rather than a universal rule

"Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers"

ROS also disrupt intercellular junction proteins (e.g., vascular endothelial cadherin, VE-cadherin) in vascular endothelial cells, impairing the endothelial barrier