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Nanoscale 9 (31), 1110311118 (2017) T.A

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In addition, it should be noted that the maintenance of RPE after the BR supplement consumption can be the result of decreased central motor command due to the contractile operation maintained during the exercise (102), as RPE displays a central feedback process in which a motor order output is dispatched from the motor zones to the sensory brain to allow conscious awareness of the actions relevant to motor yield (103)

Participants saw rapid initial loss through weeks 4 to 12, peak velocity between weeks 12 and 24 (roughly 1.8 pounds per week), gradual slowing between weeks 24 and 36, and a plateau or near-plateau by weeks 44 to 48