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additionally, the mitigate liver inflammation, support pancreatic -cell survival, and improve insulin sensitivity and metabolic stability in intensive care units (ICUs) (39)

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Grape seed procyanidin activates peroxisome proliferator-activated receptor (PPAR), thereby downregulating the expression of cyclooxygenase 2 (COX-2), achieving the regulation of lipid metabolism, inhibiting cell proliferation, blocking the inflammatory cascade, alleviating vascular inflammation, and reversing the vascular structural remodeling of PASMCs (Liu et al., 2020)