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Further Western blot analysis showed that RRM2 regulated the expression levels of MMP2, MMP9 and EMT-related proteins (N-Cadherin, Vimentin, Snail), suggesting that RRM2 may promote tumor cell invasion and metastasis by promoting matrix degradation and inducing epithelial mesenchymal transition
10, 2022, Wheeler ML, Pi-Sunyer FX
Methods An in vitro model of PCOS was constructed by treating KGN cells with dihydrotestosterone (DHT), and PLB treatment, YTHDF1 knockdown (si-YTHDF1), and SLC7A5 overexpression (pcDNA 3.1-SLC7A5) were intervened respectively