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Aim for 2.5-3 liters of water daily during active episodes
Women made up 56% of the Phase 2 trial cohort (89 out of 157 participants at the 12mg dose)
its use is not approved by the FDA) insurance is far less likely to cover it
There is also the very real possibility there will be continual churn among GLP-1 users, as people cycle on and off the drugs throughout their lifetime
However, patients should not self-treat severe or persistent constipation without medical advice, especially if they develop pain, bloating, vomiting, inability to pass stool or gas, or rectal bleeding
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