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32,107,234 Interestingly, in contrast to this, a recent study concluded that central and peripheral GLP-1 systems suppress eating via independent gut-brain circuits in mice
While body weight and metabolic phenotypes remain the primary endpoints, the outcome spectrum is progressively extending toward lipotoxic load [e.g., hepatic fat and visceral adipose tissue (VAT)], inflammatory/cardiometabolic risk markers, and reproductive outcomes with higher clinical decision-making value, such as menstruation, ovulation, and pregnancy
it does not imply medical superiority
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Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
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