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BMI over 27 with a weight-related condition: This includes individuals who have high blood pressure, type 2 diabetes, or high cholesterol

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However, while TL satisfactorily meets the criteria 3 and 4 of the American Federation for Aging Research due to an opportunity to a minimally invasive, repeated testing without harm to human subjects and a testability in both laboratory animals and humans, its compliance with the criteria 1 and 2 is rather questionable (Sanders and Newman, 2013)