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The preceding effects are attributable to modulation of reward-related brain regions (e.g., mesolimbic dopamine system), resulting in nicotine aversion

From preclinical evidence to human studies: what makes a drug candidate ready for a First-in-Human trial

This process is especially important during physical activity, as it helps the body utilise fat stores for fuel, supporting both endurance and weight management goals

But these benefits need careful weighing against heart risks - particularly if you have health conditions or caffeine sensitivity [42]

The impact of synbiotic treatment on the levels of gut-derived uremic toxins, inflammation, and gut microbiome of chronic kidney disease patients-a randomized trial