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The most commonly reported side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which occur in a substantial proportion of patients, particularly during dose escalation

Reduced dopamine signaling decreases the psychological component of arousal

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In trials, cholelithiasis was reported in 1.1% of tirzepatide-treated patients and 1% of placebo-treated patients, and cholecystitis was seen in 0.7% and 0.2%, respectively