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The pathogenic link between PsA and T2DM is not yet fully understood, but inflammatory cytokines, particularly TNF and IL-17, are known to impair insulin signaling and promote insulin resistance [61]

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97 However, rare cases have been reported of individuals who have one of these mutations and do not develop dementia symptoms until late life

Negative staining and data processing The complex samples were diluted to 0.006mg/mL in 20mM HEPES pH 7.4, 100mM NaCl, 2mM MgCl 2 and 1M peptide and applied to the continuous carbon grids (EMS)

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