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Evidence-based lifestyle changesincluding weight loss, increased physical activity, and dietary improvementsremain the cornerstone of NAFLD management

In the new substudy, once weekly semaglutide (1 mg) was shown to reduce the risk of time to first composite HF event (new onset or worsening HF leading to unscheduled hospital admission or urgent visit, with initiation of or intensified diuretic/vasoactive therapy) or cardiovascular death and HF events and cardiovascular death alone

Over the past decades, the pathophysiology of obesity has been extensively investigated, and an increasing number of signal transduction pathways have been implicated in obesity, making it possible to fight obesity in a more effective and precise way

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What this means for planning Semaglutide is not a cure