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Hashimotos thyroiditis is particularly common in those with PA

Consider allergy or mast-cell evaluation when Hives, swelling or wheezing are prominent Symptoms occur without a clear food-histamine relationship Multiple environmental or medication triggers are present Episodes are systemic or severe Consider broader functional evaluation when Chronic diarrhea or malabsorption is present Food restriction keeps expanding Symptoms began after infection or major gastrointestinal disruption Diet and DAO provide only partial benefit A Practical Step-by-Step Plan Identify the dominant pattern Determine whether symptoms are mainly meal-related, allergy-related, mast-cell-like or associated with a persistent mood and behavioral pattern

Under physiological conditions, Fe 2+ in the blood is oxidized by ceruloplasmin (CP) to Fe 3+ , which then combines with transferrin (TF) to form transferrin-bound iron (TBI) [26]

Appendix B

Biochem-Moscow 55(10):13971402 Barros MH, McStay GP (2020) Modular biogenesis of mitochondrial respiratory complexes