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( F ) Viability of Pfa1 and xCT OE cells after 72 h of incubation with Tam (0.5 M) and Lipr (1 M), as measured with an ATP assay (left panel) and a PrestoBlue cell viability assay (right panel)

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Recommended protocol: Washout: 25 to 30 days Starting dose: 2mg weekly Week 5: escalate to 4mg Week 9: escalate to 8mg Week 13: escalate to 12mg based on response This accelerated schedule saves 4 weeks compared to the standard titration