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Phase 2 trial: the study that started it all The Phase 2 trial, published in the New England Journal of Medicine under the title "Triple Hormone Receptor Agonist Retatrutide for Obesity," is the foundation upon which the entire Phase 3 program was built

Patients who were prescribed phentermine after losing fewer than 20 pounds while on a GLP-1 receptor agonist were more likely to lose weight 1 year after GLP-1 discontinuation than those who were not prescribed phentermine, recent findings show

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Sutton said the success many people have seen using semaglutide is also a important reminder that obesity is a chronic medical condition