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Additional information Peer review information Nature Nanotechnology thanks Yizhou Dong, Mingzhao Zhu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Increased Lean Body Mass: The mean increase in the lean body mass of the participants across different studies was about 4.7lb

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Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis

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