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9 Summary The available literature indicates that non-medical use of exogenous testosterone and other anabolicandrogenic steroids (AAS) is associated with a broad spectrum of multisystem adverse effects mediated by oxidative stress, mitochondrial dysfunction, endocrine disruption, and epigenetic mechanisms
therefore, while suppression is often noticed early, it usually intensifies as the dosage is gradually titrated up over several months
and third, to critically appraise the clinical evidence supporting such interventions while acknowledging their risks and limitations
2022;71(S1):S57S70
Furthermore, metformin treatment is demonstrated to enhance radiosensitivity in vitro and in xenograft models of colon cancer (30, 31) and pancreatic cancer (47)
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