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While humans lack the nicotinamidase enzyme needed to convert NAM directly to NA, bacteria contain nicotinamidase and can deaminate NAM to NA.[2830] Gut microflora can also synthesize NAD from niacin and produce niacin equivalents from tryptophan.[3133] Niacin biosynthesis is present in the majority of the human gut microflora genomes: 63% of all investigated gut microflora genomes contained one or more NAD biosynthesis pathways.[33] Similar to other tissues, the gut also uses niacin equivalents for its needs

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This delivery system successfully traversed the blood-brain barrier (BBB), improved the transport of DMC to dopaminergic neurons and microglia in the substantia nigra pars compacta of Parkinsons disease (PD) mice, and intervened in PD (270)

They also saw increased binding of NRF2 at the GCLC promoter under LSD1 siRNA along with increased GCLC expression

The difference significantly impacts both safety and treatment outcomes