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The conclusion was that a 10% increase in the proportion of ultra-processed food in the diet was associated with significantly higher rates of cardiovascular disease, coronary heart disease, and cerebrovascular disease (an increase of 12%, 13%, and 11%, respectively). Meanwhile, a diet higher in unprocessed or minimally processed foods is correlated with a lower risk of all these health issues

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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review