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Muscle protein synthesis was not measured, so it remains to be established whether these effects apply to muscle or other tissues

Limited Human Data Human research involving these peptides is: small-scale narrowly focused not designed to establish long-term safety insufficient for determining risk in broader contexts As a result, long-term biological effects remain unknown

Merchenthaler et al., 2004

Source: FDA briefing document, July 2026

The presented mechanism, that uses a thiolate group as intramolecular base, is among those possible, one that has an analogy (however remote) with one that has already been recognized as biochemically occurring