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For instance, federal health officials have launched a new program to make the current crop of weight-loss drugs available to older Medicare patients who are struggling with obesity

"Semaglutide is the most validated GLP-1 medicine in outcomes trials, with demonstrated benefits across atherosclerotic CVD, HFpEF, CKD, MASH, OSA, and osteoarthritis," he says

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Some lean mass loss can occur during any major weight-loss program including GLP-1 treatment but recent research suggests the muscle loss may not be as severe as experts once feared

Last reviewed: June 5, 2026 Last updated: June 5, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations