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10.1016/j.freeradbiomed.2010.09.019 Free Radic

Conclusions In this meta-analysis of 100,196 patients, across the full spectrum of those with and without prior ASCVD and/or T2DM, GLP-1RA demonstrated significant reduction of MI risk by 12% with NNT of 248 to prevent one event of MI

A 2023 analysis of the SUSTAIN and PIONEER trials published in Cardiovascular Diabetology showed significant reductions in high-sensitivity C-reactive protein, a marker of systemic inflammation, among patients taking semaglutide

When insulin binds to its receptor, these IPGs are generated by hydrolysis of glycosylphosphatidylinositol (GPI) lipids and/or specific proteins located on the outer part of the cell membrane