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5,6,9 Aerobic exercise has been shown to activate muscle glucose transport by an insulin- independent mechanism, enabling the normal processing of dietary glucose into muscle glycogen and energy

That makes the combination easy to understand clinically, even while the final product remains investigational

Further analysis revealed that AKT1 is also highly associated with key metabolic nodes, including adenine nucleotides (ATP, AMP), glutamic acid, and intermediates of the TCA cycle, suggesting a rewiring of the metabolic landscape toward increased energy demand, redox activity, and utilization of carbon and nitrogen substrates

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PMID 15662292