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The pharmacy benefit manager Prime Therapeutics released a study in October stating that findings indicate in the real world that individuals taking GLP-1 therapies without diabetes [over a two year period] will see no medical cost offset. Analysis of health insurance claims showed that the treatments did not lower other medical costs

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1) and lower SOD (Mann-Whitney, Z = 2.18, P = 0.013

Hormonal Influences While On Mounjaro Tirzepatide does not directly alter sex hormone production, but indirect hormonal shifts can occur as metabolic health improves

The glucagon receptor agonism component is relatively novel in this context, and its downstream effects on the hypothalamic-pituitary-gonadal axis which governs sex hormone production have not been formally studied in published retatrutide trials