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The PK stability profile in mice of our early fusions such as Ab#2_GLP1 and Ab#2_EX4 demonstrated that the in vivo GLP-1R activity of such peptide-antibody fusion molecules rapidly decreased over time due to peptide degradation compared to the exposure achieved by the antibody Fc component (Fig

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However, such a toxic effect of the combination of acetylsalicylic acid and VPA may have a synergistic killing effect on the proliferation and apoptosis of hepatocellular cancer cells [124]