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Cellular ROS, as indicated by DCF fluorescence, and lipid peroxidation, as indicated by C11-BODIPY fluorescence (Fig

Small molecule inhibitors of ARG2 have been shown to upregulate the immune activity and almost completely counteract the immunosuppression, suggesting that ARG2 can be used as a target for the immunotherapy of AML (Mussai et al., 2013)

This does not invalidate the data, but it means the evidence base is narrower than the publication volume implies

Unknown Risks with Prolonged Use: As with any treatment, the long-term effects beyond a decade of continuous use are not fully studied, emphasizing the need for periodic medical evaluations

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