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Self-prescribing unlicensed peptides carries real and potentially serious health risks

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Participants with obesity (a body-mass index [BMI] of 30) and a clinical and radiologic diagnosis of moderate knee osteoarthritis with at least moderate pain were randomly assigned 2:1 to receive once-weekly subcutaneous semaglutide (2.4 mg) or placebo, in addition to counseling on physical activity and a reduced-calorie diet

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By using a metabolites-based framework, approximately 20% of the microbial genome has the potential for 5-HT synthesis (Valles-Colomer et al., 2019)