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The Phase 2 trial results Published in the New England Journal of Medicine, the Phase 2 trial showed that participants receiving the highest dose of retatrutide (12mg weekly) achieved a mean weight reduction of 24.2% at 48 weeks

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Vrkonyi T, Del Prato S, Pavo I, Nicolay C, Wiese RJ, Kahn SE

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Semaglutide came later, building on everything researchers learned from liraglutide