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Upon activation, SKN-1 and CncC upregulate genes involved in the oxidative stress response, including many orthologs of those regulated by mammalian NRF2 (Sykiotis and Bohmann, 2008), and can significantly increase longevity (Sykiotis and Bohmann, 2008

It then inhibits adipocyte lipolysis and increases FFAs in cells, further stimulating the LDLs accumulation and secretion, inducing lipid metabolism disorders, lipotoxicity, and even cell necrosis, finally resulting in diabetic myocardial damage

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Indeed, chronic pain and gastrointestinal disturbances (e.g., nausea and diarrhea) observed in patients with endometriosis can lead to appetite loss and subsequent caloric restriction [28]