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These drugs also reshape reward pathways tied to emotion, compulsion, and craving

Patients with type 1 DM are generally diagnosed earlier in life 41

Animal studies show mostly mild local irritation at injection sites

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The 1998 Raun characterisation paper documented that ipamorelin stimulated GH release in pigs and rats with potency comparable to GHRP-6 but without the prolactin, ACTH, cortisol, or aldosterone elevations characteristic of earlier GHRPs (PMID 9849822)