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Certain individuals are more likely to develop B12 deficiency, including those with: Pernicious anemia Gastrointestinal conditions (such as Crohns disease or celiac disease) A history of gastrointestinal surgery Difficulty absorbing nutrients due to age or other medical conditions For these patients, vitamin B12 injections are an effective option because they deliver the nutrient directly into the bloodstream, bypassing the digestive system and ensuring optimal absorption

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cdc.gov Malhotra A, et al

Thus, a PD- specific biomarker would be useful for differential diagnosis in cases of non-classical presentation

Histone deacetylase 11 is an -N-myristoyllysine hydrolase