When high doses of LDopa are administered chronically, there is an increased demand for SAM as a methyl-group donor (Uncini et al
Mouse model of B12 deficiency Female C57BL/6 and SCID mice were fed with a diet similar to control group normal diet (Teklad 2014S, ENVIGO), but with no added B12 and with 5% Pectin (Tekland custom diet TD.170206, ENVIGO)
Vitamin B12 is water-soluble, so any excess is naturally excreted by the body, reducing the risk of toxicity
Gastrointestinal Issues: Vitamin B12 deficiency can affect the gastrointestinal tract, leading to symptoms such as diarrhea, constipation, loss of appetite, and weight loss
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